The Classics in Medicine series by 2 Minute Medicine is now on MedShr Learning. In this volume, 13 landmark clinical trials in General Chronic Disease and Cardiology are explored, covering topics from antiarrhytmic agents in myocardial infarction  to rate-control vs rhythm-control in atrial fibrillation. Every physician, health professional, and trainee should have a working knowledge of these trials to both understand and make daily evidence-based clinical decisions.

With contributions from renowned medical faculty and practicing physicians at top institutions, this chapter is an indispensable tool. Some landmark trials included in this chapter are the HOT trial: Diastolic blood pressure targets in hypertension; the REMATCH trial: Left ventricular assist devices reduce mortality in heart failure; and the ACTIVE trial: Dual antiplatelet therapy in atrial fibrillation.