This learning module works through the investigation and diagnosis of a 75 year old female patient presenting with a gradual onset of reduced mobility and weakness. 

Formulate a list of differential diagnoses for patients presenting with gradual-onset muscle weakness.

Consider appropriate investigations and the interpretation of their results for the investigation of myopathy.

Recognise the common signs and symptoms of HMGCR immune-mediated necrotizing myopathy.

Understand the potential role of statins in patients with myopathy and how to mitigate further risk to the patient.

Myopathy has multiple causes. This neurological case follows the investigation and diagnosis of a 75 year old female who presents with reduced mobility and weakness that has developed over the preceding years. The patient is diagnosed with HMGCR antibody-associated immune-mediated necrotizing myopathy, a rare cause of myopathy that has a strong association with statin exposure.

Case Discussion: a rare cause of myopathy

Neurotransmission: A Neurology Learning Space

Neural Components

A key learning series focussing on important topics in neurology 

Laura White

This module explores cases of stroke/TIA ‘mimics,' where alternative presentations may present similarly to stroke/TIA.


Stroke and TIA mimics

Tips on recognising and managing seizures in neurosurgical practice

Seizures in the neurosurgical setting

This module explores cerebral small vessel disease (SVD), a disorder of cerebral microvessels. 

Unlocking the Secrets of Cerebral Small Vessel Disease

This expert-led learning series presents important topics and presentations in neurology.