The HOT trial in the General Chronic Disease and Cardiology Series from 2MM's The Classics In Medicine looks at diastolic blood pressure targets in hypertension

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The HOT trial: Diastolic blood pressure targets in hypertension

2 Minute Medicine™

Volume 1: General Chronic Disease and Cardiology from 2MM™ The Classics In Medicine

The Classics in Medicine series by 2 Minute Medicine is now on MedShr Learning. In this volume, 13 landmark clinical trials in General Chronic Disease and Cardiology are explored, covering topics from antiarrhytmic agents in myocardial infarction  to rate-control vs rhythm-control in atrial fibrillation. Every physician, health professional, and trainee should have a working knowledge of these trials to both understand and make daily evidence-based clinical decisions.
With contributions from renowned medical faculty and practicing physicians at top institutions, this chapter is an indispensable tool. Some landmark trials included in this chapter are the HOT trial: Diastolic blood pressure targets in hypertension; the REMATCH trial: Left ventricular assist devices reduce mortality in heart failure; and the ACTIVE trial: Dual antiplatelet therapy in atrial fibrillation.
With contributions from renowned medical faculty and practicing physicians at top institutions, this chapter is an indispensable tool for the practicing physician or trainee. Some landmark trials included in this chapter are the HOT trial: Diastolic blood pressure targets in hypertension; the REMATCH trial: Left ventricular assist devices reduce mortality in heart failure; and the ACTIVE trial: Dual antiplatelet therapy in atrial fibrillation.

The remaining chapters from the textbook edition are organized into Classics by Specialty and includes trials from the following fields: General Chronic Disease and Cardiology, Critical and Emergent Care, Endocrinology, Gastroenterology, Hematology and Oncology, Imaging, Infectious Disease, Nephrology, Neurology, Pediatrics, Psychiatry, Pulmonology, Surgery, and COVID-19. More coming soon! 


Dominic Hampson

The HMPS I trial: Adverse events in patients and negligence in the General Chronic Disease and Cardiology series from 2MM's The Classics In Medicine

The HMPS I trial: Adverse events in patients and negligence

The DASH trial in the General Chronic Disease and Cardiology series from 2MM's The Classics In Medicine, explores how diet change significantly reduces blood pressure

The DASH trial: Diet change significantly reduces blood pressure

The UKPDS study in the General Chronic Disease and Cardiology series from 2MM's The Classics In Medicine investigated reducing diabetes-related morbidity and mortality

The UKPDS: Reducing diabetes-related morbidity and mortality

The STAR*D trials I: Medication augmentation for depression in the General Chronic Disease and Cardiology series from 2MM's The Classics In Medicine

The STAR*D trials I: Medication augmentation for depression 

 The CATIE trial in the General Chronic Disease and Cardiology series from 2MM's The Classics In Medicine

The CATIE trial: High rates of medication discontinuation in schizophrenic patients

The STAR*D trials II study in the General Chronic Disease and Cardiology series from 2MM™'s The Classics In Medicine

The STAR*D trials II: Switching antidepressants in depression management

Symptom-triggered benzodiazepine treatment for alcohol withdrawal in the General Chronic Disease and Cardiology series from 2MM™'s The Classics In Medicine

Symptom-triggered benzodiazepine treatment for alcohol withdrawal

 The ENHANCE trial in the General Chronic Disease and Cardiology series from 2MM'™s The Classics In Medicine

The ENHANCE trial: Simvastatin and ezetimibe in familial hypercholesterolemia

The RAVE trial in the General Chronic Disease and Cardiology series from 2MM's The Classics In Medicine

The RAVE trial: Rituximab induces remission in ANCA-associated vasculitis

The JUPITER trial in the General Chronic Disease and Cardiology series from 2MM's The Classics In Medicine

The JUPITER: Rosuvastatin reduces the risk of major cardiovascular events in healthy patients

What did the LRC-CPPT report about cholestyramine and coronary heart disease outcomes in middle-aged men? Explore this early lipid-lowering trial through 2 Minute Medicine’s expert summary.

The LRC-CPPT 1: Cholestyramine and coronary heart disease

How did V-HeFT I evaluate hydralazine plus isosorbide dinitrate in systolic heart failure compared with placebo? Learn through 2 Minute Medicine’s expert summary. 

The V-HeFT I: Hydralazine and isosorbide dinitrate reduce mortality in heart failure

The Classics in Medicine series by 2 Minute Medicine is now on MedShr Learning. In this volume, 13 landmark clinical trials in General Chronic Disease and Cardiology are explored, covering topics from antiarrhytmic agents in myocardial infarction &nbsp;to rate-control vs rhythm-control in atrial fibrillation. Every physician, health professional, and trainee should have a working knowledge of these trials to both understand and make daily evidence-based clinical decisions.With contributions from renowned medical faculty and practicing physicians at top institutions, this chapter is an indispensable tool. Some landmark trials included in this chapter are the HOT trial: Diastolic blood pressure targets in hypertension; the REMATCH trial: Left ventricular assist devices reduce mortality in heart failure; and the ACTIVE trial: Dual antiplatelet therapy in atrial fibrillation.