Coronavirus COVID-19 Daily Update 20th March 2020

This update will be published daily at 12pm GMT and aims to provide clinicians and the public with an overview of the latest data, guidelines, key publications and policy around COVID-19, with links to essential resources and information.

If you are a healthcare professional, please join the discussion on these latest COVID-19 cases on MedShr:

Please post any COVID-19 cases, images or learning points from your clinical practice on MedShr - share key knowledge and experience with a global network of doctors to help improve patient care. Include #COVID19 in your case title.

Please email COVID@medshr.net if you have any data, publications or information you would like to share.

Global Impact of COVID-19 to Date

As of 20th March 10:00 (GMT)

Source: Johns Hopkins University & Medicine

COVID-19 Cumulative Global Cases

As of 19th March 09:00 (GMT)

Source: World Health Organisation

COVID-19 Global Active Cases Map

As of 20th March 10:00 GMT

Source: Johns Hopkins University & Medicine

Total UK COVID-19 Cases

As of 19th March 09:00

Source: Public Health England

COVID-19 Cumulative UK Cases

As of 19th March 09:00

Source: Public Health England

COVID-19 Daily UK Cases

As of 19th March 09:00 (GMT)

Source: Public Health England

Latest Developments

Italy

COVID-19 death toll in Italy has now reached 3,405, surpassing China

Italy Ministry of Health Website

China

China reports no new domestic cases of COVID-19 for the 2nd consecutive day

Chinese Website of the Commission for Health

USA

California placed on lockdown

Centers for Disease Control and Prevention website

US Coronavirus (COVID-19) website

Official Coronavirus (COVID-19) in California website

United Kingdom

Schools closing today

Significant increase in COVID-19 cases

Trials to begin on a COVID-19 vaccine next month

UK Government Advice

Reproduction and Fatality for Selected Human Viruses

This graph provides a comparison of the reproduction number and case-fatality ratio of COVID-19 against other viruses.

Source: McKinsey & Company

COVID-19 Case Fatality Rate by Age

The elderly are at a greatly increased risk of mortality.

Source: McKinsey & Company

Disease Phases Around the World

As of 16th March 09:00 (GMT)

Source: McKinsey & Company

COVID-19 Transmission Complexes

As of 16th March 09:00 (GMT)

Source: McKinsey & Company

Latest COVID-19 Publications

Some key recent publications to be aware of:

According to this article, the overall symptomatic case fatality risk of COVID-19 in Wuhan, China, was 1.4% as of February 29. This figure is substantially lower than previously thought.

This study evaluated the efficacy and safety of oral lopinavir–ritonavir for SARS-CoV-2 infection, but found that, in hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care.

This article discusses some of the immediate and long-term cardiovascular implications of viral infection and the significant gaps in knowledge that future research will need to address.

Author: Dr Daniel Livingstone, MedShr - Health Education England Fellow