covid-19

Coronavirus COVID-19 Daily Update 23rd March 2020

Daniel Livingstone
Tags
COVID19

Coronavirus COVID-19 Daily Update 21st March 2020

This update will be published daily at 12pm GMT and aims to provide clinicians and the public with an overview of the latest data, guidelines, key publications and policy around COVID-19, with links to essential resources and information.

If you are a healthcare professional, please join the discussion on these latest COVID-19 cases on MedShr:

Please post any COVID-19 cases, images or learning points from your clinical practice on MedShr - share key knowledge and experience with a global network of doctors to help improve patient care. Include #COVID19 in your case title.

Please email COVID@medshr.net if you have any data, publications or information you would like to share.

Global Impact of COVID-19 to Date

As of 23rd March 10:00 (GMT)

COVID-19 Cumulative Global Cases

As of 22nd March 09:00 (GMT)

COVID-19 Global Active Cases Map

As of 23rd March 10:00 GMT

Total UK COVID-19 Cases

As of 22nd March 09:00 (GMT)

COVID-19 Cumulative UK Cases

As of 22nd March 09:00 (GMT)

COVID-19 Daily UK Cases

As of 22nd March 09:00 (GMT)

The importance of social distancing!

COVID-19 (SARS-CoV-2) and surfaces: rapid time-decay of viral load

Source: J. P. Morgan

Some promising news in development of anti-viral medications

Source: J. P. Morgan

UK Critical Care Bed Capacity

Source: J. P. Morgan

Infection and mortality rates by age and pre-existing co-morbidities

Source: J. P. Morgan

Case fatality during and after Spanish Flu

Source: J. P. Morgan

Hospital Beds and COVID-19 Testing by Country

Source: J. P. Morgan

Reproduction and Fatality for Selected Human Viruses

This graph provides a comparison of the reproduction number and case-fatality ratio of COVID-19 against other viruses.

COVID-19 Case Fatality Rate by Age

The elderly are at a greatly increased risk of mortality.

Latest COVID-19 Publications

Some key recent publications to be aware of:

This paper summarises the clinical and radiologic characteristics of 27 confirmed cases of COVID-19 and analyses the association of radiological findings with mortality cases.

This article found that the mean viral load of severe COVID-19 cases was around 60 times higher than that of mild cases, suggesting that higher viral loads might be associated with severe clinical outcomes. Mild cases were found to have an early viral clearance, with 90% of these patients repeatedly testing negative on RT-PCR by day 10 post-onset. By contrast, all severe cases still tested positive at or beyond day 10 post-onset. The data suggests that, similar to SARS in 2002–03, patients with severe COVID-19 tend to have a high viral load and a long virus-shedding period, hence the viral load of SARS-CoV-2 might be a useful marker for assessing disease severity and prognosis.

This prospective longitudinal study systematically describes the temporal changes of CT findings in COVID-19 pneumonia and summarises the CT findings at the time of hospital discharge. The extent of lung abnormalities on CT peaked during illness days 6-11. The temporal changes of the diverse CT manifestations followed a specific pattern, which might indicate the progression and recovery of the illness.

Author: Dr Daniel Livingstone, MedShr - Health Education England Fellow

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