Coronavirus COVID-19 Weekly Update 23rd November 2020
Weekly update published on MedShr: 23rd November 2020
Last updated: 23rd November 2020
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Coronavirus COVID-19 Weekly Update 23rd November 2020
This update will be published weekly at 12pm GMT on Mondays and aims to provide clinicians and the public with an overview of the latest data, guidelines, key publications and policy around COVID-19, with links to essential resources and information.
If you are a healthcare professional, please join the discussion on these latest COVID-19 cases on MedShr:
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Global Impact of COVID-19 to Date
WHO official data, reported on 22nd Nov 2020
COVID-19 Cumulative Global Cases
WHO official data, reported on 22nd Nov 2020
Source: World Health Organization
Total UK COVID-19 Cases
As of 23rd Nov 09:00 (GMT) - Data for 24 hour period, reported on 22-11-20
Source: Public Health England
COVID-19 in the African Region
As of 23rd Nov 09:00 (GMT) - Data for 24 hour period, reported on 22-11-20
Source: World Health Organization
COVID-19 in the Eastern Mediterranean Region
As of 23rd Nov 09:00 (GMT) - Data for 24 hour period, reported on 22-11-20
Source: World Health Organization
Latest COVID-19 Publications and Guidelines:
A selection of recent publications and useful clinical guidance from scientific journals:
Editorials, Research Articles and Commentary:
Ramasamy MN, Minassian AM, Ewer KJ, et al. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. The Lancet. Doi: 10.1016/S0140-6736(20)32466-1
Ashish A, Unsworth A, Martindale J, Sundar R, Kavuri K, Sedda L, Farrier M. CPAP management of COVID-19 respiratory failure: a first quantitative analysis from an inpatient service evaluation. BMJ Open Respir Res. 2020 Nov;7(1):e000692. doi: 10.1136/bmjresp-2020-000692. PMID: 33148777; PMCID: PMC7643430.
Yanes-Lane M, Winters N, Fregonese F, Bastos M, Perlman-Arrow S, Campbell JR, Menzies D. Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis. PLoS One. 2020 Nov 3;15(11):e0241536. doi: 10.1371/journal.pone.0241536. PMID: 33141862; PMCID: PMC7608887.
medRxiv: Phase II Clinical trial for Evaluation of BCG as potential therapy for COVID-19 (preprint)
Padmanabhan U, Mukherjee S, Borse R, Joshi S, Deshmukh R. Phase II Clinical trial for Evaluation of BCG as potential therapy for COVID-19. medRxiv 2020 [preprint].10.28.20221630; doi: https://doi.org/10.1101/2020.10.28.20221630
BMJ: A living WHO guideline on drugs for covid-19 (Update 1)
Rochwerg B, Agoritsas T, Lamontagne F, et al. Update 1: A living WHO guideline on drugs for covid-19. BMJ. 2020 Sep 4;370:m3379. doi: 10.1136/bmj.m3379. PMID: 32887691.
Am J Trop Med Hyg: Fighting COVID-19 at the Expense of Malaria in Africa: The Consequences and Policy Options
Aborode AT, David KB, Uwishema O, Nathaniel AL, Imisioluwa JO, Onigbinde SB, Farooq F. Fighting COVID-19 at the Expense of Malaria in Africa: The Consequences and Policy Options. Am J Trop Med Hyg. 2020 Nov 11. doi: 10.4269/ajtmh.20-1181. Epub ahead of print. PMID: 33205743.
Lenze EJ, Mattar C, Zorumski CF, Stevens A, Schweiger J, Nicol GE, Miller JP, Yang L, Yingling M, Avidan MS, Reiersen AM. Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial. JAMA. 2020 Nov 12:e2022760. doi: 10.1001/jama.2020.22760. Epub ahead of print. PMID: 33180097; PMCID: PMC7662481.
Nature Human Behaviour: Real-time, interactive website for US-county-level COVID-19 event risk assessment
Chande A, Lee S, Harris M, Nguyen Q, Beckett SJ, Hilley T, Andris C, Weitz JS. Real-time, interactive website for US-county-level COVID-19 event risk assessment. Nat Hum Behav. 2020 Nov 9. doi: 10.1038/s41562-020-01000-9. Epub ahead of print. PMID: 33168955.
Latest Developments in the News:
WHO Weekly Situational Reports: Epidemiological and Operational
Africa
WHO: WHO urges greater COVID-19 vigilance in Africa as holidays near
WHO: Nearly 1 in 5 COVID-19 deaths in the African region linked to diabetes
BBC: Coronavirus in Africa tracker
WHO in the African Region: COVID-19
Eastern Mediterranean
The Lancet: Tackling COVID-19 in the Eastern Mediterranean Region (comment)
BBC: Covid: Gaza health system 'days from being overwhelmed'
WHO: Regional COVID-19 response: success stories
WHO in the Eastern Mediterranean Region: COVID-19
United Kingdom
BBC: Covid-19: Oxford University vaccine shows 70% protection
BMA: BMA sets out COVID-19 lockdown exit strategy
BBC: Covid: Oxford vaccine shows 'encouraging' immune response in older adults
BBC: Covid: Gyms and all shops to reopen after English lockdown
The Lancet: Urgent actions and policies needed to address COVID-19 among UK ethnic minorities (comment)
BMA: A lead role in defeating the virus
Coronavirus (COVID-19) in the UK
Global Health
The Lancet: Age and frailty in COVID-19 vaccine development
BMJ: Covid-19: What now for remdesivir?
Nature: How to stop restaurants from driving COVID infections
Nature: Immune responses to coronavirus persist beyond 6 months
BMJ: Long covid: Damage to multiple organs presents in young, low risk patients
JAMA: Best Practices for COVID-19–Positive or Exposed Mothers—Breastfeeding and Pumping Milk
PAHO (WHO): PAHO calls for improving diabetes control to prevent complications and severe COVID-19
WHO: WHO establishes Council on the Economics of Health for All
MSF: Governments must support proposal to waive coronavirus COVID-19 patents
Useful Sources for Latest Developments and News
WHO: Coronavirus disease (COVID-19) pandemic (including links to regional offices)
United Nations: COVID-19 Response
Johns Hopkins University & Medicine: Coronavirus Resource Center
Centers for Disease Control and Prevention
European Centre for Disease Prevention and Control
Médecins Sans Frontières: Response and News Articles
BBC: Covid-19 pandemic: Tracking the global coronavirus outbreak
Financial Times: Coronavirus tracker: the latest figures as countries fight Covid-19 resurgence
Harvard Medical School: Coronavirus Resource Center
Our World in Data: Coronavirus Pandemic (COVID-19) - Statistics and Research
Educational Resources:
WHO: COVID-19 Course Series
"Real-time training during global emergencies is critical for effective preparedness and response. The COVID-19 channel provides learning resources for health professionals, decision-makers and the public for the outbreak of coronavirus disease (COVID-19)." (WHO 2020)
MedShr Open: COVID-19 Weekly Article - Seasonal Influenza
Did you miss our COVID-19 Open Article on the challenges of managing Seasonal Influenza during the COVID-19 pandemic? This article also considers the challenges of mass vaccination for both COVID-19 and Seasonal Influenza.
Public Health Emergency COVID-19 Initiative - PubMed Central
An open collection of COVID-19 and coronavirus-related publications, and the available data supporting them, from over 50 publishers to support the ongoing public health emergency response efforts (PMC).
Other Useful Resources:
Intensive Care Society (UK) Covid-19 Resource Hub
The Mid Yorkshire Hospitals NHS Trust COVID-19 Bulletins - A weekly bulletin detailing the "latest guidelines, research and reports relating to COVID-19"
NHS England: Coronavirus guidance for clinicians and NHS managers
Weekly Update by Dr Ryan Broll, MedShr Open Editorial Team, Medical Education Fellow
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