Coronavirus COVID-19 Weekly Update 23rd November 2020

Coronavirus COVID-19 Weekly Update 23rd November 2020

Weekly update published on MedShr: 23rd November 2020
Last updated: 23rd November 2020

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Coronavirus COVID-19 Weekly Update 23rd November 2020

This update will be published weekly at 12pm GMT on Mondays and aims to provide clinicians and the public with an overview of the latest data, guidelines, key publications and policy around COVID-19, with links to essential resources and information.

If you are a healthcare professional, please join the discussion on these latest COVID-19 cases on MedShr:

Please post any COVID-19 cases, images or learning points from your clinical practice on MedShr - share key knowledge and experience with a global network of doctors to help improve patient care. Include #COVID19 in your case title.

Please email COVID@medshr.net if you have any data, publications or information you would like to share.


Global Impact of COVID-19 to Date

WHO official data, reported on 22nd Nov 2020

COVID-19 Cumulative Global Cases

WHO official data, reported on 22nd Nov 2020

Total UK COVID-19 Cases

As of 23rd Nov 09:00 (GMT) - Data for 24 hour period, reported on 22-11-20

Total UK daily cases over past month

COVID-19 in the African Region

As of 23rd Nov 09:00 (GMT) - Data for 24 hour period, reported on 22-11-20

COVID-19 in the Eastern Mediterranean Region

As of 23rd Nov 09:00 (GMT) - Data for 24 hour period, reported on 22-11-20

Latest COVID-19 Publications and Guidelines:

A selection of recent publications and useful clinical guidance from scientific journals:


Editorials, Research Articles and Commentary:

The Lancet: Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Ramasamy MN, Minassian AM, Ewer KJ, et al. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. The Lancet. Doi: 10.1016/S0140-6736(20)32466-1 

BMJ: CPAP management of COVID-19 respiratory failure: a first quantitative analysis from an inpatient service evaluation

Ashish A, Unsworth A, Martindale J, Sundar R, Kavuri K, Sedda L, Farrier M. CPAP management of COVID-19 respiratory failure: a first quantitative analysis from an inpatient service evaluation. BMJ Open Respir Res. 2020 Nov;7(1):e000692. doi: 10.1136/bmjresp-2020-000692. PMID: 33148777; PMCID: PMC7643430.

PLOS One: Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis

Yanes-Lane M, Winters N, Fregonese F, Bastos M, Perlman-Arrow S, Campbell JR, Menzies D. Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis. PLoS One. 2020 Nov 3;15(11):e0241536. doi: 10.1371/journal.pone.0241536. PMID: 33141862; PMCID: PMC7608887.

medRxiv: Phase II Clinical trial for Evaluation of BCG as potential therapy for COVID-19 (preprint)

Padmanabhan U, Mukherjee S, Borse R, Joshi S, Deshmukh R. Phase II Clinical trial for Evaluation of BCG as potential therapy for COVID-19. medRxiv 2020 [preprint].10.28.20221630; doi: https://doi.org/10.1101/2020.10.28.20221630

BMJ: A living WHO guideline on drugs for covid-19 (Update 1)

Rochwerg B, Agoritsas T, Lamontagne F, et al. Update 1: A living WHO guideline on drugs for covid-19. BMJ. 2020 Sep 4;370:m3379. doi: 10.1136/bmj.m3379. PMID: 32887691.

Am J Trop Med Hyg: Fighting COVID-19 at the Expense of Malaria in Africa: The Consequences and Policy Options

Aborode AT, David KB, Uwishema O, Nathaniel AL, Imisioluwa JO, Onigbinde SB, Farooq F. Fighting COVID-19 at the Expense of Malaria in Africa: The Consequences and Policy Options. Am J Trop Med Hyg. 2020 Nov 11. doi: 10.4269/ajtmh.20-1181. Epub ahead of print. PMID: 33205743.

JAMA: Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial

Lenze EJ, Mattar C, Zorumski CF, Stevens A, Schweiger J, Nicol GE, Miller JP, Yang L, Yingling M, Avidan MS, Reiersen AM. Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial. JAMA. 2020 Nov 12:e2022760. doi: 10.1001/jama.2020.22760. Epub ahead of print. PMID: 33180097; PMCID: PMC7662481.

Nature Human Behaviour: Real-time, interactive website for US-county-level COVID-19 event risk assessment 

Chande A, Lee S, Harris M, Nguyen Q, Beckett SJ, Hilley T, Andris C, Weitz JS. Real-time, interactive website for US-county-level COVID-19 event risk assessment. Nat Hum Behav. 2020 Nov 9. doi: 10.1038/s41562-020-01000-9. Epub ahead of print. PMID: 33168955.


Latest Developments in the News:

WHO Weekly Situational Reports: Epidemiological and Operational


Africa

WHO: WHO urges greater COVID-19 vigilance in Africa as holidays near

WHO: Nearly 1 in 5 COVID-19 deaths in the African region linked to diabetes

BBC: Coronavirus in Africa tracker

WHO in the African Region: COVID-19


Eastern Mediterranean

The Lancet: Tackling COVID-19 in the Eastern Mediterranean Region (comment)

WHO: Prioritizing a transition from psychiatric hospital-based to community-based mental health services in Iraq

BBC: Covid: Gaza health system 'days from being overwhelmed'

WHO: Regional COVID-19 response: success stories

WHO in the Eastern Mediterranean Region: COVID-19


United Kingdom

BBC: Covid-19: Oxford University vaccine shows 70% protection

BMA: BMA sets out COVID-19 lockdown exit strategy

BBC: Covid: Oxford vaccine shows 'encouraging' immune response in older adults 

BBC: Covid: Gyms and all shops to reopen after English lockdown

The Lancet: Urgent actions and policies needed to address COVID-19 among UK ethnic minorities (comment)

BMA: A lead role in defeating the virus

UK Government Advice

Coronavirus (COVID-19) in the UK


Global Health

The Lancet: Age and frailty in COVID-19 vaccine development

BMJ: Covid-19: What now for remdesivir?

UNICEF: UNICEF calls for averting a lost generation as COVID-19 threatens to cause irreversible harm to children’s education, nutrition and well-being

Nature: How to stop restaurants from driving COVID infections 

Nature: Immune responses to coronavirus persist beyond 6 months

BMJ: Long covid: Damage to multiple organs presents in young, low risk patients

JAMA: Best Practices for COVID-19–Positive or Exposed Mothers—Breastfeeding and Pumping Milk

PAHO (WHO): PAHO calls for improving diabetes control to prevent complications and severe COVID-19

WHO: WHO establishes Council on the Economics of Health for All

MSF: Governments must support proposal to waive coronavirus COVID-19 patents

UNICEF: COVAX Update: UNICEF working with global airlines and freight providers to plan delivery of COVID-19 vaccines


Useful Sources for Latest Developments and News

WHO: Coronavirus disease (COVID-19) pandemic (including links to regional offices)

United Nations: COVID-19 Response

Johns Hopkins University & Medicine: Coronavirus Resource Center

Centers for Disease Control and Prevention

European Centre for Disease Prevention and Control

Médecins Sans Frontières: Response and News Articles

BBC: Covid-19 pandemic: Tracking the global coronavirus outbreak

Financial Times: Coronavirus tracker: the latest figures as countries fight Covid-19 resurgence

Harvard Medical School: Coronavirus Resource Center

Our World in Data: Coronavirus Pandemic (COVID-19) - Statistics and Research


Educational Resources:


WHO: COVID-19 Course Series

"Real-time training during global emergencies is critical for effective preparedness and response. The COVID-19 channel provides learning resources for health professionals, decision-makers and the public for the outbreak of coronavirus disease (COVID-19)." (WHO 2020)


MedShr Open: COVID-19 Weekly Article - Seasonal Influenza

Did you miss our COVID-19 Open Article on the challenges of managing Seasonal Influenza during the COVID-19 pandemic? This article also considers the challenges of mass vaccination for both COVID-19 and Seasonal Influenza.


Public Health Emergency COVID-19 Initiative - PubMed Central

An open collection of COVID-19 and coronavirus-related publications, and the available data supporting them, from over 50 publishers to support the ongoing public health emergency response efforts (PMC).

Other Useful Resources:

Intensive Care Society (UK) Covid-19 Resource Hub

The Mid Yorkshire Hospitals NHS Trust COVID-19 Bulletins - A weekly bulletin detailing the "latest guidelines, research and reports relating to COVID-19"

NHS England: Coronavirus guidance for clinicians and NHS managers

CDC: COVID-19 Science Updates


Weekly Update by Dr Ryan Broll, MedShr Open Editorial Team, Medical Education Fellow

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