Coronavirus COVID-19 Weekly Update 29th March 2021

Coronavirus COVID-19 Weekly Update 29th March 2021

Weekly update published on MedShr: 29th March 2021
Last updated: 29th March 2021

Every effort has been made to ensure that the information contained in this article is accurate and current at time of publication, but if you notice an error please contact covid@medshr.net and we will aim to address this. Please find MedShr’s full terms of service here.


Coronavirus COVID-19 Weekly Update 29th March 2021

This update will be published weekly at 12pm GMT on Mondays and aims to provide clinicians and the public with an overview of the latest data, guidelines, key publications and policy around COVID-19, with links to essential resources and information.

If you are a healthcare professional, please join the discussion on these latest COVID-19 cases on MedShr:

Please post any anonymous educational COVID-19 cases, images or learning points from your clinical practice on MedShr - share key knowledge and experience with a global network of doctors to help improve patient care. Include #COVID19 in your case title.

Please email COVID@medshr.net if you have any data, publications or information you would like to share.


Global Impact of COVID-19 to Date

Data from WHO Coronavirus Disease (COVID-19) Dashboard, reported on 28th March 2021

Sources: World Health Organization, Johns Hopkins University & Medicine

Data related to 'patients recovered' and 'countries affected' based on data from Johns Hopkins University & Medicine, other data obtained from WHO Coronavirus Disease (COVID-19) Dashboard.


COVID-19 Cumulative Global Cases

Data from WHO Coronavirus Disease (COVID-19) Dashboard, reported on 28th March 2021

Global Vaccinations Against COVID-19

Official data collated by Our World in Data - data up to 29th March 2021 at 11:13 (GMT)

Source: Our World in Data

For full vaccination data, Our World in Data state: "Total number of people who received all doses prescribed by the vaccination protocol. This data is only available for countries which report the breakdown of doses administered by first and second doses."


Total UK COVID-19 Cases

As of 29th March 09:00 (GMT) - Data for 24 hour period, reported on 28-03-21

UK total daily cases over past month

COVID-19 in the African Region

As of 29th March 09:00 (GMT) - Data for 24 hour period, reported on 28-03-21

COVID-19 in the Eastern Mediterranean Region

As of 29th March 09:00 (GMT) - Data for 24 hour period, reported on 28-03-21

Latest COVID-19 Publications and Guidelines:

A selection of recent publications and useful clinical guidance from scientific journals


The Lancet: Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Voysey M, Costa Clemens SA, Madhi SA, et al. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021 Mar 6;397(10277):881-891. doi: 10.1016/S0140-6736(21)00432-3. Epub 2021 Feb 19. Erratum in: Lancet. 2021 Mar 6;397(10277):880. PMID: 33617777; PMCID: PMC7894131.

JAMA: Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial 

Grieco DL, Menga LS, Cesarano M, et al. Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial. JAMA. 2021 Mar 25. doi: 10.1001/jama.2021.4682. Epub ahead of print. PMID: 33764378.

The Lancet: Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study

He Z, Ren L, Yang J, et al. Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study. Lancet. 2021 Mar 20;397(10279):1075-1084. doi: 10.1016/S0140-6736(21)00238-5. PMID: 33743869.

BMJ: Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England

Forbes H, Morton CE, Bacon S, et al. Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England. BMJ. 2021 Mar 18;372:n628. doi: 10.1136/bmj.n628. PMID: 33737413; PMCID: PMC7970340.

The Lancet Infectious Diseases: Vaccination and non-pharmaceutical interventions for COVID-19: a mathematical modelling study

Moore S, Hill EM, Tildesley MJ, et al. Vaccination and non-pharmaceutical interventions for COVID-19: a mathematical modelling study. Lancet Infect Dis. 2021 Mar 18:S1473-3099(21)00143-2. doi: 10.1016/S1473-3099(21)00143-2. Epub ahead of print. PMID: 33743847.

Ann Intern Med: Quantification of Occupational and Community Risk Factors for SARS-CoV-2 Seropositivity Among Health Care Workers in a Large U.S. Health Care System

Baker JM, Nelson KN, Overton E, et al. Quantification of Occupational and Community Risk Factors for SARS-CoV-2 Seropositivity Among Health Care Workers in a Large U.S. Health Care System. Ann Intern Med. 2021 Jan 29:M20-7145. doi: 10.7326/M20-7145. Epub ahead of print. PMID: 33513035; PMCID: PMC7877798.

Nature Communications: Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

Wang Z, Yang X, Zhong J, et al. Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection. Nat Commun. 2021 Mar 19;12(1):1724. doi: 10.1038/s41467-021-22036-z. PMID: 33741972.

BMJ: Assessing risk for healthcare workers during the covid-19 pandemic

Khunti K, Griffiths A, Majeed A, et al. Assessing risk for healthcare workers during the covid-19 pandemic. BMJ. 2021 Mar 15;372:n602. doi: 10.1136/bmj.n602. PMID: 33722904.

JACC Cardiovasc Imaging: High Prevalence of Pericardial Involvement in College Student Athletes Recovering From COVID-19

Brito D, Meester S, Yanamala N, et al. High Prevalence of Pericardial Involvement in College Student Athletes Recovering From COVID-19. JACC Cardiovasc Imaging. 2021 Mar;14(3):541-555. doi: 10.1016/j.jcmg.2020.10.023. Epub 2020 Nov 4. PMID: 33223496; PMCID: PMC7641597.


Educational Resources:


WHO: COVID-19 Course Series

"Real-time training during global emergencies is critical for effective preparedness and response. The COVID-19 channel provides learning resources for health professionals, decision-makers and the public for the outbreak of coronavirus disease (COVID-19)." (WHO 2020)

WHO: Vaccine Series

Science: How do the leading COVID-19 vaccines work? Science explains

Johns Hopkins University: Understanding the COVID-19 Pandemic

BMJ Best Practice: Coronavirus disease 2019 (COVID-19) clinical decision support tool

Elsevier: COVID-19 Health Education resource center, including the Health Education Faculty Hub

NEJM: Covid-19 Vaccine Resource Center

NEJM: Delayed Second Dose versus Standard Regimen for Covid-19 Vaccination

Nature: Coronapod: the Oxford-AstraZeneca COVID vaccine - what you need to know (26th March 2021)

BMJ: A living WHO guideline on drugs to prevent covid-19

BMJ: Severe covid-19 pneumonia: pathogenesis and clinical management

BMJ: What is my covid risk?


MedShr Open: COVID-19 Articles

The COVID-19 Hub on MedShr Open includes a selection of articles covering a range of topics related to COVID-19, ranging from emerging therapies, long-term effects of COVID-19, and considering the effects of the pandemic on other essential healthcare services.


Global Health Data for COVID-19

Global.health - a Data Science Initiative - open public health COVID-19 dataset to advance the response to infectious diseases

The Institute for Health Metrics and Evaluation (IHME)


Research related to COVID-19

Below is a list of links to organisations who are making great efforts to categorise, evaluate and summarise the vast catalogue of COVID-19 research. If you discover any other great resources please feel free to share these in the comments section below.

Global research on coronavirus disease (COVID-19) - WHO Global research database and links to further research catalogues

LitCovid - a curated literature hub for tracking up-to-date scientific information about COVID-19

Public Health Emergency COVID-19 Initiative - PubMed Central

COVID-19 Science Updates - Centers for Disease Control and Prevention

Coronavirus Disease 2019 (COVID-19) Treatment Guidelines - National Institutes of Health

ClinicalTrials.gov - COVID-19 clinical trials

Finding the evidence: Coronavirus – Knowledge & Library Services - Public Health England

Coronavirus (COVID-19) - Cochrane resources and news - Cochrane



Weekly Update by Dr Ryan Broll, MedShr Open Editorial Team, Medical Education Fellow

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