Coronavirus COVID-19 Weekly Update 29th March 2021
Weekly update published on MedShr: 29th March 2021
Last updated: 29th March 2021
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Coronavirus COVID-19 Weekly Update 29th March 2021
This update will be published weekly at 12pm GMT on Mondays and aims to provide clinicians and the public with an overview of the latest data, guidelines, key publications and policy around COVID-19, with links to essential resources and information.
If you are a healthcare professional, please join the discussion on these latest COVID-19 cases on MedShr:
Please post any anonymous educational COVID-19 cases, images or learning points from your clinical practice on MedShr - share key knowledge and experience with a global network of doctors to help improve patient care. Include #COVID19 in your case title.
Please email COVID@medshr.net if you have any data, publications or information you would like to share.
Global Impact of COVID-19 to Date
Data from WHO Coronavirus Disease (COVID-19) Dashboard, reported on 28th March 2021
Sources: World Health Organization, Johns Hopkins University & Medicine
Data related to 'patients recovered' and 'countries affected' based on data from Johns Hopkins University & Medicine, other data obtained from WHO Coronavirus Disease (COVID-19) Dashboard.
COVID-19 Cumulative Global Cases
Data from WHO Coronavirus Disease (COVID-19) Dashboard, reported on 28th March 2021
Source: World Health Organization
Global Vaccinations Against COVID-19
Official data collated by Our World in Data - data up to 29th March 2021 at 11:13 (GMT)
Source: Our World in Data
For full vaccination data, Our World in Data state: "Total number of people who received all doses prescribed by the vaccination protocol. This data is only available for countries which report the breakdown of doses administered by first and second doses."
Total UK COVID-19 Cases
As of 29th March 09:00 (GMT) - Data for 24 hour period, reported on 28-03-21
Source: Public Health England
COVID-19 in the African Region
As of 29th March 09:00 (GMT) - Data for 24 hour period, reported on 28-03-21
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Source: World Health Organization
COVID-19 in the Eastern Mediterranean Region
As of 29th March 09:00 (GMT) - Data for 24 hour period, reported on 28-03-21
Source: World Health Organization
Latest COVID-19 Publications and Guidelines:
A selection of recent publications and useful clinical guidance from scientific journals
Voysey M, Costa Clemens SA, Madhi SA, et al. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021 Mar 6;397(10277):881-891. doi: 10.1016/S0140-6736(21)00432-3. Epub 2021 Feb 19. Erratum in: Lancet. 2021 Mar 6;397(10277):880. PMID: 33617777; PMCID: PMC7894131.
Grieco DL, Menga LS, Cesarano M, et al. Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial. JAMA. 2021 Mar 25. doi: 10.1001/jama.2021.4682. Epub ahead of print. PMID: 33764378.
He Z, Ren L, Yang J, et al. Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study. Lancet. 2021 Mar 20;397(10279):1075-1084. doi: 10.1016/S0140-6736(21)00238-5. PMID: 33743869.
Forbes H, Morton CE, Bacon S, et al. Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England. BMJ. 2021 Mar 18;372:n628. doi: 10.1136/bmj.n628. PMID: 33737413; PMCID: PMC7970340.
The Lancet Infectious Diseases: Vaccination and non-pharmaceutical interventions for COVID-19: a mathematical modelling study
Moore S, Hill EM, Tildesley MJ, et al. Vaccination and non-pharmaceutical interventions for COVID-19: a mathematical modelling study. Lancet Infect Dis. 2021 Mar 18:S1473-3099(21)00143-2. doi: 10.1016/S1473-3099(21)00143-2. Epub ahead of print. PMID: 33743847.
Baker JM, Nelson KN, Overton E, et al. Quantification of Occupational and Community Risk Factors for SARS-CoV-2 Seropositivity Among Health Care Workers in a Large U.S. Health Care System. Ann Intern Med. 2021 Jan 29:M20-7145. doi: 10.7326/M20-7145. Epub ahead of print. PMID: 33513035; PMCID: PMC7877798.
Nature Communications: Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection
Wang Z, Yang X, Zhong J, et al. Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection. Nat Commun. 2021 Mar 19;12(1):1724. doi: 10.1038/s41467-021-22036-z. PMID: 33741972.
BMJ: Assessing risk for healthcare workers during the covid-19 pandemic
Khunti K, Griffiths A, Majeed A, et al. Assessing risk for healthcare workers during the covid-19 pandemic. BMJ. 2021 Mar 15;372:n602. doi: 10.1136/bmj.n602. PMID: 33722904.
JACC Cardiovasc Imaging: High Prevalence of Pericardial Involvement in College Student Athletes Recovering From COVID-19
Brito D, Meester S, Yanamala N, et al. High Prevalence of Pericardial Involvement in College Student Athletes Recovering From COVID-19. JACC Cardiovasc Imaging. 2021 Mar;14(3):541-555. doi: 10.1016/j.jcmg.2020.10.023. Epub 2020 Nov 4. PMID: 33223496; PMCID: PMC7641597.
Educational Resources:
"Real-time training during global emergencies is critical for effective preparedness and response. The COVID-19 channel provides learning resources for health professionals, decision-makers and the public for the outbreak of coronavirus disease (COVID-19)." (WHO 2020)
WHO: Vaccine Series
Science: How do the leading COVID-19 vaccines work? Science explains
Johns Hopkins University: Understanding the COVID-19 Pandemic
BMJ Best Practice: Coronavirus disease 2019 (COVID-19) - clinical decision support tool
Elsevier: COVID-19 Health Education resource center, including the Health Education Faculty Hub
NEJM: Covid-19 Vaccine Resource Center
NEJM: Delayed Second Dose versus Standard Regimen for Covid-19 Vaccination
Nature: Coronapod: the Oxford-AstraZeneca COVID vaccine - what you need to know (26th March 2021)
BMJ: A living WHO guideline on drugs to prevent covid-19
BMJ: Severe covid-19 pneumonia: pathogenesis and clinical management
MedShr Open: COVID-19 Articles
The COVID-19 Hub on MedShr Open includes a selection of articles covering a range of topics related to COVID-19, ranging from emerging therapies, long-term effects of COVID-19, and considering the effects of the pandemic on other essential healthcare services.
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Global Health Data for COVID-19
Global.health - a Data Science Initiative - open public health COVID-19 dataset to advance the response to infectious diseases
The Institute for Health Metrics and Evaluation (IHME)
Research related to COVID-19
Below is a list of links to organisations who are making great efforts to categorise, evaluate and summarise the vast catalogue of COVID-19 research. If you discover any other great resources please feel free to share these in the comments section below.
Global research on coronavirus disease (COVID-19) - WHO Global research database and links to further research catalogues
LitCovid - a curated literature hub for tracking up-to-date scientific information about COVID-19
Public Health Emergency COVID-19 Initiative - PubMed Central
COVID-19 Science Updates - Centers for Disease Control and Prevention
Coronavirus Disease 2019 (COVID-19) Treatment Guidelines - National Institutes of Health
ClinicalTrials.gov - COVID-19 clinical trials
Finding the evidence: Coronavirus – Knowledge & Library Services - Public Health England
Coronavirus (COVID-19) - Cochrane resources and news - Cochrane
Weekly Update by Dr Ryan Broll, MedShr Open Editorial Team, Medical Education Fellow
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